Medication-assisted treatment (MAT) is a comprehensive approach to addressing substance use disorders that combines behavioral therapies with medications that help manage withdrawal symptoms and cravings. This type of treatment is commonly used for opioid addiction, but can also be effective for alcohol and other substance use disorders. MAT can improve patient outcomes, reduce the risk of relapse, and increase retention in treatment programs. Some of the medications commonly used in MAT include methadone, buprenorphine, and naltrexone. MAT is considered an evidence-based practice and is recommended by organizations such as the Substance Abuse and Mental Health Services Administration (SAMHSA) and the National Institute on Drug Abuse (NIDA).